Smad2 Is Essential for Maintenance of the Human and Mouse Primed Pluripotent Stem Cell State

Human embryonic stem cells and mouse epiblast stem cells represent a primed pluripotent stem cell state that requires TGF-β/activin signaling. TGF-β and/or activin are commonly thought to regulate transcription through both Smad2 and Smad3. However, the different contributions of these two Smads to...

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Bibliographic Details
Main Authors: Sakaki-Yumoto, Masayo, Liu, Jianming, Ramalho-Santos, Miguel, Yoshida, Nobuaki, Derynck, Rik
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3689995/
https://ncbi.nlm.nih.gov/pubmed/23649632
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446591
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