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Biological effects of simple changes in functionality on rhodium metalloinsertors
DNA mismatch repair (MMR) is crucial to ensuring the fidelity of the genome. The inability to correct single base mismatches leads to elevated mutation rates and carcinogenesis. Using metalloinsertors–bulky metal complexes that bind with high specificity to mismatched sites in the DNA duplex–our lab...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The Royal Society Publishing
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3685451/ https://ncbi.nlm.nih.gov/pubmed/23776288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsta.2012.0117 |
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