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Chemical Genomics Identifies Small-Molecule MCL1 Repressors and BCL-xL as a Predictor of MCL1 Dependency
MCL1, which encodes the anti-apoptotic protein MCL1, is among the most frequently amplified genes in human cancer. A chemical genomic screen identified compounds, including anthracyclines, that decreased MCL1 expression. Genomic profiling indicated that those compounds were global transcriptional re...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3685408/ https://ncbi.nlm.nih.gov/pubmed/22516262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.02.028 |
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