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Inhibition of Antiapoptotic BCL-XL, BCL-2, and MCL-1 Proteins by Small Molecule Mimetics

Informatics and computational design methods were used to create new molecules that could potentially bind antiapoptotic proteins, thus promoting death of cancer cells. Apoptosis is a cellular process that leads to the death of damaged cells. Its malfunction can cause cancer and poor response to con...

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Autors principals: Dalafave, D.S., Prisco, G.
Format: Artigo
Idioma:Inglês
Publicat: Libertas Academica 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935820/
https://ncbi.nlm.nih.gov/pubmed/20838611
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