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Alterations to the remote control of Shh gene expression cause congenital abnormalities

Multi-species conserved non-coding elements occur in the vertebrate genome and are clustered in the vicinity of developmentally regulated genes. Many are known to act as cis-regulators of transcription and may reside at long distances from the genes they regulate. However, the relationship of conser...

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Hlavní autoři: Hill, Robert E., Lettice, Laura A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682722/
https://ncbi.nlm.nih.gov/pubmed/23650631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rstb.2012.0357
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