PDE3, but not PDE4, reduces β(1)- and β(2)-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

BACKGROUND AND PURPOSE: PDE3 and/or PDE4 control ventricular effects of catecholamines in several species but their relative effects in failing human ventricle are unknown. We investigated whether the PDE3-selective inhibitor cilostamide (0.3–1 μM) or PDE4 inhibitor rolipram (1–10 μM) modified the p...

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Hlavní autoři: Molenaar, Peter, Christ, Torsten, Hussain, Rizwan I, Engel, Andreas, Berk, Emanuel, Gillette, Katherine T, Chen, Lu, Galindo-Tovar, Alejandro, Krobert, Kurt A, Ravens, Ursula, Levy, Finn Olav, Kaumann, Alberto J
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2013
Témata:
Research Paper with Commentary
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682702/
https://ncbi.nlm.nih.gov/pubmed/23489141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12167
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