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Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (−)-adrenaline mediated through mouse cardiac β(1)-adrenoceptors
BACKGROUND AND PURPOSE: β(1) and β(2)-adrenoceptors coexist in murine heart but β(2)-adrenoceptor-mediated effects have not been detected in atrial and ventricular tissues, possibly due to marked phosphodiesterase (PDE) activity. We investigated the influence of the PDE3 inhibitor cilostamide and PD...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2259196/ https://ncbi.nlm.nih.gov/pubmed/18084319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707631 |
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