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Phosphodiesterase-4 blunts inotropism and arrhythmias but not sinoatrial tachycardia of (−)-adrenaline mediated through mouse cardiac β(1)-adrenoceptors

BACKGROUND AND PURPOSE: β(1) and β(2)-adrenoceptors coexist in murine heart but β(2)-adrenoceptor-mediated effects have not been detected in atrial and ventricular tissues, possibly due to marked phosphodiesterase (PDE) activity. We investigated the influence of the PDE3 inhibitor cilostamide and PD...

詳細記述

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書誌詳細
主要な著者: Galindo-Tovar, A, Kaumann, A J
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2259196/
https://ncbi.nlm.nih.gov/pubmed/18084319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707631
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