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Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle
1. The cardiostimulant effects of CGP12177, mediated through a β(1)-adrenoceptor site with low affinity for (−)-propranolol, are potentiated by the nonselective PDE inhibitor IBMX but the role of PDE isoenzymes is unknown. We studied the effects of the PDE3-selective inhibitor cilostamide (300 nM) a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1615855/ https://ncbi.nlm.nih.gov/pubmed/16331293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706498 |
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