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Phosphodiesterase PDE3 blunts the positive inotropic and cyclic AMP enhancing effects of CGP12177 but not of noradrenaline in rat ventricle

1. The cardiostimulant effects of CGP12177, mediated through a β(1)-adrenoceptor site with low affinity for (−)-propranolol, are potentiated by the nonselective PDE inhibitor IBMX but the role of PDE isoenzymes is unknown. We studied the effects of the PDE3-selective inhibitor cilostamide (300 nM) a...

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Autors principals: Vargas, Maria Luisa, Hernandez, Jesus, Kaumann, Alberto J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2005
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1615855/
https://ncbi.nlm.nih.gov/pubmed/16331293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0706498
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