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Differential regulation of β(2)-adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle

BACKGROUND AND PURPOSE: β-Adrenoceptors play a major role in regulating myocardial function through cAMP-dependent pathways. Different phosphodiesterases (PDEs) regulate intracellular cAMP-pools and thereby contribute to the compartmentalization of cAMP-dependent effects. We explored the involvement...

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Detalhes bibliográficos
Main Authors: Afzal, Faraz, Aronsen, Jan Magnus, Moltzau, Lise Román, Sjaastad, Ivar, Levy, Finn Olav, Skomedal, Tor, Osnes, Jan-Bjørn, Qvigstad, Eirik
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012406/
https://ncbi.nlm.nih.gov/pubmed/21133887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00890.x
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