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The Hbs1-Dom34 Protein Complex Functions in Non-stop mRNA Decay in Mammalian Cells
In yeast, aberrant mRNAs lacking in-frame termination codons are recognized and degraded by the non-stop decay (NSD) pathway. The recognition of non-stop mRNAs involves a member of the eRF3 family of GTP-binding proteins, Ski7. Ski7 is thought to bind the ribosome stalled at the 3′-end of the mRNA p...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3682582/ https://ncbi.nlm.nih.gov/pubmed/23667253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.448977 |
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