Chargement en cours...

Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

Neurofibrillary pathology of abnormally hyperphosphorylated Tau is a key lesion of Alzheimer disease and other tauopathies, and its density in the brain directly correlates with dementia. The phosphorylation of Tau is regulated by protein phosphatase 2A, which in turn is regulated by inhibitor 2, I(...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Basurto-Islas, Gustavo, Grundke-Iqbal, Inge, Tung, Yunn Chyn, Liu, Fei, Iqbal, Khalid
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682549/
https://ncbi.nlm.nih.gov/pubmed/23640887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446070
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!