Tau passive immunization blocks seeding and spread of Alzheimer hyperphosphorylated Tau-induced pathology in 3 × Tg-AD mice

BACKGROUND: Accumulating evidence indicates that Tau pathology can spread from neuron to neuron by intake and coaggregation of the hyperphosphorylated Tau (p-Tau) seeds with the host neuron protein. Thus, clearance of Tau seeds by immunization with Tau antibodies could provide a potential therapeuti...

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Библиографические подробности
Опубликовано в: :Alzheimers Res Ther
Главные авторы: Dai, Chun-ling, Hu, Wen, Tung, Yunn Chyn, Liu, Fei, Gong, Cheng-Xin, Iqbal, Khalid
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2018
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5793372/
https://ncbi.nlm.nih.gov/pubmed/29386065
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-018-0341-7
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