Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

Neurofibrillary pathology of abnormally hyperphosphorylated Tau is a key lesion of Alzheimer disease and other tauopathies, and its density in the brain directly correlates with dementia. The phosphorylation of Tau is regulated by protein phosphatase 2A, which in turn is regulated by inhibitor 2, I(...

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Bibliographic Details
Main Authors: Basurto-Islas, Gustavo, Grundke-Iqbal, Inge, Tung, Yunn Chyn, Liu, Fei, Iqbal, Khalid
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682549/
https://ncbi.nlm.nih.gov/pubmed/23640887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446070
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