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Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

Neurofibrillary pathology of abnormally hyperphosphorylated Tau is a key lesion of Alzheimer disease and other tauopathies, and its density in the brain directly correlates with dementia. The phosphorylation of Tau is regulated by protein phosphatase 2A, which in turn is regulated by inhibitor 2, I(...

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Bibliografische gegevens
Hoofdauteurs: Basurto-Islas, Gustavo, Grundke-Iqbal, Inge, Tung, Yunn Chyn, Liu, Fei, Iqbal, Khalid
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682549/
https://ncbi.nlm.nih.gov/pubmed/23640887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446070
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