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Activation of Asparaginyl Endopeptidase Leads to Tau Hyperphosphorylation in Alzheimer Disease

Neurofibrillary pathology of abnormally hyperphosphorylated Tau is a key lesion of Alzheimer disease and other tauopathies, and its density in the brain directly correlates with dementia. The phosphorylation of Tau is regulated by protein phosphatase 2A, which in turn is regulated by inhibitor 2, I(...

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Hlavní autoři: Basurto-Islas, Gustavo, Grundke-Iqbal, Inge, Tung, Yunn Chyn, Liu, Fei, Iqbal, Khalid
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682549/
https://ncbi.nlm.nih.gov/pubmed/23640887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446070
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