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Cytoplasmic Retention of Protein Phosphatase 2A Inhibitor 2 (I(2)(PP2A)) Induces Alzheimer-like Abnormal Hyperphosphorylation of Tau

Abnormal hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles, a hallmark of Alzheimer disease (AD), and related tauopathies. The phosphorylation of Tau is regulated by protein phosphatase 2A (PP2A), which in turn is modulated by endogenous inhibitor 2 (I(2)(PP2A)). In AD br...

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Detalhes bibliográficos
Main Authors: Arif, Mohammad, Wei, Jianshe, Zhang, Qi, Liu, Fei, Basurto-Islas, Gustavo, Grundke-Iqbal, Inge, Iqbal, Khalid
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183805/
https://ncbi.nlm.nih.gov/pubmed/25128526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565358
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