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Cytoplasmic Retention of Protein Phosphatase 2A Inhibitor 2 (I(2)(PP2A)) Induces Alzheimer-like Abnormal Hyperphosphorylation of Tau
Abnormal hyperphosphorylation of Tau leads to the formation of neurofibrillary tangles, a hallmark of Alzheimer disease (AD), and related tauopathies. The phosphorylation of Tau is regulated by protein phosphatase 2A (PP2A), which in turn is modulated by endogenous inhibitor 2 (I(2)(PP2A)). In AD br...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183805/ https://ncbi.nlm.nih.gov/pubmed/25128526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565358 |
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