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Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

Brain glucose uptake/metabolism is impaired in Alzheimer disease (AD). Here, we report that levels of the two major brain glucose transporters (GLUT1 and GLUT3) responsible for glucose uptake into neurons were decreased in AD brain. This decrease correlated to the decrease in O-GlcNAcylation, to the...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Liu, Ying, Liu, Fei, Iqbal, Khalid, Grundke-Iqbal, Inge, Gong, Cheng-Xin
פורמט: Artigo
שפה:Inglês
יצא לאור: 2008
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2247364/
https://ncbi.nlm.nih.gov/pubmed/18174027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.12.035
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