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Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease
Brain glucose uptake/metabolism is impaired in Alzheimer disease (AD). Here, we report that levels of the two major brain glucose transporters (GLUT1 and GLUT3) responsible for glucose uptake into neurons were decreased in AD brain. This decrease correlated to the decrease in O-GlcNAcylation, to the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2247364/ https://ncbi.nlm.nih.gov/pubmed/18174027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.12.035 |
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