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Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease

Brain glucose uptake/metabolism is impaired in Alzheimer disease (AD). Here, we report that levels of the two major brain glucose transporters (GLUT1 and GLUT3) responsible for glucose uptake into neurons were decreased in AD brain. This decrease correlated to the decrease in O-GlcNAcylation, to the...

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保存先:
書誌詳細
主要な著者: Liu, Ying, Liu, Fei, Iqbal, Khalid, Grundke-Iqbal, Inge, Gong, Cheng-Xin
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2247364/
https://ncbi.nlm.nih.gov/pubmed/18174027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2007.12.035
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