Dephosphorylation Passivates the Seeding Activity of Oligomeric Tau Derived From Alzheimer’s Brain

Accumulation of intracellular neurofibrillary tangles (NFTs), which are constituted of abnormally phosphorylated tau, is one of the neuropathological hallmarks of Alzheimer’s disease (AD). The oligomeric aggregates of tau in AD brain (AD O-tau) are believed to trigger NFT spreading by seeding normal...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Wu, Ruozhen, Li, Longfei, Shi, Ruirui, Zhou, Yan, Jin, Nana, Gu, Jianlan, Tung, Yunn Chyn, Liu, Fei, Chu, Dandan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8155256/
https://ncbi.nlm.nih.gov/pubmed/34054426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2021.631833
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