The DNAJB6 and DNAJB8 Protein Chaperones Prevent Intracellular Aggregation of Polyglutamine Peptides

Fragments of proteins containing an expanded polyglutamine (polyQ) tract are thought to initiate aggregation and toxicity in at least nine neurodegenerative diseases, including Huntington's disease. Because proteasomes appear unable to digest the polyQ tract, which can initiate intracellular pr...

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Detalhes bibliográficos
Main Authors: Gillis, Judith, Schipper-Krom, Sabine, Juenemann, Katrin, Gruber, Anna, Coolen, Silvia, van den Nieuwendijk, Rian, van Veen, Henk, Overkleeft, Hermen, Goedhart, Joachim, Kampinga, Harm H., Reits, Eric A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682527/
https://ncbi.nlm.nih.gov/pubmed/23612975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421685
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