DNAJB6 is a peptide-binding chaperone which can suppress amyloid fibrillation of polyglutamine peptides at substoichiometric molar ratios

Expanded polyglutamine (polyQ) stretches lead to protein aggregation and severe neurodegenerative diseases. A highly efficient suppressor of polyQ aggregation was identified, the DNAJB6, when molecular chaperones from the HSPH, HSPA, and DNAJ families were screened for huntingtin exon 1 aggregation...

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Autores principales: Månsson, Cecilia, Kakkar, Vaishali, Monsellier, Elodie, Sourigues, Yannick, Härmark, Johan, Kampinga, Harm H., Melki, Ronald, Emanuelsson, Cecilia
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Netherlands 2013
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Original Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3933622/
https://ncbi.nlm.nih.gov/pubmed/23904097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12192-013-0448-5
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