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Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch

Expanded polyglutamine (polyQ) stretches in at least nine unrelated proteins lead to inherited neuronal dysfunction and degeneration. The expansion size in all diseases correlates with age at onset (AO) of disease and with polyQ protein aggregation, indicating that the expanded polyQ stretch is the...

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Detalles Bibliográficos
Publicado en:Front Neurosci
Autores principales: Kuiper, E. F. E., de Mattos, Eduardo P., Jardim, Laura B., Kampinga, Harm H., Bergink, Steven
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2017
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362620/
https://ncbi.nlm.nih.gov/pubmed/28386214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00145
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