Chaperones in Polyglutamine Aggregation: Beyond the Q-Stretch

Expanded polyglutamine (polyQ) stretches in at least nine unrelated proteins lead to inherited neuronal dysfunction and degeneration. The expansion size in all diseases correlates with age at onset (AO) of disease and with polyQ protein aggregation, indicating that the expanded polyQ stretch is the...

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Bibliographic Details
Published in:Front Neurosci
Main Authors: Kuiper, E. F. E., de Mattos, Eduardo P., Jardim, Laura B., Kampinga, Harm H., Bergink, Steven
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Neuroscience
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5362620/
https://ncbi.nlm.nih.gov/pubmed/28386214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2017.00145
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