The DNAJB6 and DNAJB8 Protein Chaperones Prevent Intracellular Aggregation of Polyglutamine Peptides

Fragments of proteins containing an expanded polyglutamine (polyQ) tract are thought to initiate aggregation and toxicity in at least nine neurodegenerative diseases, including Huntington's disease. Because proteasomes appear unable to digest the polyQ tract, which can initiate intracellular pr...

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Dettagli Bibliografici
Autori principali: Gillis, Judith, Schipper-Krom, Sabine, Juenemann, Katrin, Gruber, Anna, Coolen, Silvia, van den Nieuwendijk, Rian, van Veen, Henk, Overkleeft, Hermen, Goedhart, Joachim, Kampinga, Harm H., Reits, Eric A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Cell Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3682527/
https://ncbi.nlm.nih.gov/pubmed/23612975
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.421685
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