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Co-chaperones DNAJA1 and DNAJB6 are critical for regulation of polyglutamine aggregation
Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin gene. The expanded polyglutamine (polyQ) repeat of the encoded protein leads to protein misfolding and aggregation, resulting in increased neuronal cell death. DNAJ co-chaperones play a crucial role in transferring misfold...
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| Yayımlandı: | Sci Rep |
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| Asıl Yazarlar: | , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group UK
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7235262/ https://ncbi.nlm.nih.gov/pubmed/32424160 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-65046-5 |
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