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Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity
The formation of insoluble protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by proteins with expanded polyglutamine (polyQ) repeats. However, the mechanistic relationship between polyQ aggregation and its toxic effects on neurons remains unclear. Two main hypotheses h...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC139902/ https://ncbi.nlm.nih.gov/pubmed/12189209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.182426899 |
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