Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity
The formation of insoluble protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by proteins with expanded polyglutamine (polyQ) repeats. However, the mechanistic relationship between polyQ aggregation and its toxic effects on neurons remains unclear. Two main hypotheses h...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139902/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12189209/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182426899 |
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