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Cofactor Tpr2 combines two TPR domains and a J domain to regulate the Hsp70/Hsp90 chaperone system

In the eukaryotic cytosol, Hsp70 and Hsp90 cooperate with various co-chaperone proteins in the folding of a growing set of substrates, including the glucocorticoid receptor (GR). Here, we analyse the function of the co-chaperone Tpr2, which contains two chaperone-binding TPR domains and a DnaJ homol...

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Udgivet i:EMBO J
Principais autores: Brychzy, Alexander, Rein, Theo, Winklhofer, Konstanze F., Hartl, F.Ulrich, Young, Jason C., Obermann, Wolfgang M.J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2003
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC165632/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12853476/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg362
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