Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

The formation of insoluble protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by proteins with expanded polyglutamine (polyQ) repeats. However, the mechanistic relationship between polyQ aggregation and its toxic effects on neurons remains unclear. Two main hypotheses h...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Sakahira, Hideki, Breuer, Peter, Hayer-Hartl, Manajit K., Hartl, F. Ulrich
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 2002
Fag:	Colloquium Paper
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139902/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12189209/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182426899
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