Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

The formation of insoluble protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by proteins with expanded polyglutamine (polyQ) repeats. However, the mechanistic relationship between polyQ aggregation and its toxic effects on neurons remains unclear. Two main hypotheses h...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Sakahira, Hideki, Breuer, Peter, Hayer-Hartl, Manajit K., Hartl, F. Ulrich
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2002
Matèries:	Colloquium Paper
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139902/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12189209/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182426899
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