Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity

The formation of insoluble protein aggregates in neurons is a hallmark of neurodegenerative diseases caused by proteins with expanded polyglutamine (polyQ) repeats. However, the mechanistic relationship between polyQ aggregation and its toxic effects on neurons remains unclear. Two main hypotheses h...

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Bibliografski detalji

Izdano u:	Proc Natl Acad Sci U S A
Glavni autori:	Sakahira, Hideki, Breuer, Peter, Hayer-Hartl, Manajit K., Hartl, F. Ulrich
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2002
Teme:	Colloquium Paper
Online pristup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC139902/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12189209/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.182426899
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