FOXO1 controls protein synthesis and transcript abundance of mutant polyglutamine proteins, preventing protein aggregation

FOXO1, a transcription factor downstream of the insulin/insulin like growth factor axis, has been linked to protein degradation. Elevated expression of FOXO orthologs can also prevent the aggregation of cytosine adenine guanine (CAG)-repeat disease causing polyglutamine (polyQ) proteins but whether...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Furtado, Gabriel Vasata, Yang, Jing, Wu, Di, Papagiannopoulos, Christos I, Terpstra, Hanna M, Kuiper, E F Elsiena, Krauss, Sybille, Zhu, Wei-Guo, Kampinga, Harm H, Bergink, Steven
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
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General Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8170844/
https://ncbi.nlm.nih.gov/pubmed/33822053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddab095
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