Interaction of the Molecular Chaperone DNAJB6 with Growing Amyloid-beta 42 (Aβ42) Aggregates Leads to Sub-stoichiometric Inhibition of Amyloid Formation

The human molecular chaperone protein DNAJB6 was recently found to inhibit the formation of amyloid fibrils from polyglutamine peptides associated with neurodegenerative disorders such as Huntington disease. We show in the present study that DNAJB6 also inhibits amyloid formation by an even more agg...

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Vydáno v:J Biol Chem
Hlavní autoři: Månsson, Cecilia, Arosio, Paolo, Hussein, Rasha, Kampinga, Harm H., Hashem, Reem M., Boelens, Wilbert C., Dobson, Christopher M., Knowles, Tuomas P. J., Linse, Sara, Emanuelsson, Cecilia
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Molecular Biophysics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223311/
https://ncbi.nlm.nih.gov/pubmed/25217638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595124
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