A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling

Slit is a large secreted protein that provides important guidance cues in the developing nervous system and in other organs. Signaling by Slit requires two receptors, Robo transmembrane proteins and heparan sulfate (HS) proteoglycans. How HS controls Slit-Robo signaling is unclear. Here we show that...

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Библиографические подробности
Главные авторы: Hussain, Sadaf-Ahmahni, Piper, Michael, Fukuhara, Noémi, Strochlic, Laure, Cho, Gian, Howitt, Jason A., Ahmed, Yassir, Powell, Andrew K., Turnbull, Jeremy E., Holt, Christine E., Hohenester, Erhard
Формат: Artigo
Язык:Inglês
Опубликовано: 2006
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680705/
https://ncbi.nlm.nih.gov/pubmed/17062560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M609384200
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