A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling

Slit is a large secreted protein that provides important guidance cues in the developing nervous system and in other organs. Signaling by Slit requires two receptors, Robo transmembrane proteins and heparan sulfate (HS) proteoglycans. How HS controls Slit-Robo signaling is unclear. Here we show that...

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Bibliografiset tiedot
Päätekijät: Hussain, Sadaf-Ahmahni, Piper, Michael, Fukuhara, Noémi, Strochlic, Laure, Cho, Gian, Howitt, Jason A., Ahmed, Yassir, Powell, Andrew K., Turnbull, Jeremy E., Holt, Christine E., Hohenester, Erhard
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2006
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680705/
https://ncbi.nlm.nih.gov/pubmed/17062560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M609384200
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