Panels of chemically-modified heparin polysaccharides and natural heparan sulfate saccharides both exhibit differences in binding to Slit and Robo, as well as variation between protein binding and cellular activity

Heparin/heparan sulfate (HS) glycosaminoglycans are required for Slit–Robo cellular responses. Evidence exists for interactions between each combination of Slit, Robo and heparin/HS and for formation of a ternary complex. Heparin/HS are complex mixtures displaying extensive structural diversity. The...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mol Biosyst
Auteurs principaux: Ahmed, Yassir A., Yates, Edwin A., Moss, Diana J., Loeven, Markus A., Hussain, Sadaf-Ahmahni, Hohenester, Erhard, Turnbull, Jeremy E., Powell, Andrew K.
Format: Artigo
Langue:Inglês
Publié: Royal Society of Chemistry 2016
Sujets:
Chemistry
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5048398/
https://ncbi.nlm.nih.gov/pubmed/27502551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6mb00432f
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