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Structural and Functional Analysis of Slit and Heparin Binding to Immunoglobulin-like Domains 1 and 2 of Drosophila Robo

Recognition of the secreted protein Slit by transmembrane receptors of the Robo family provides important signals in the development of the nervous system and other organs, as well as in tumor metastasis and angiogenesis. Heparan sulfate (HS) proteoglycans serve as essential co-receptors in Slit-Rob...

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Detalhes bibliográficos
Main Authors: Fukuhara, Noémi, Howitt, Jason A., Hussain, Sadaf-Ahmahni, Hohenester, Erhard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2671633/
https://ncbi.nlm.nih.gov/pubmed/18359766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M800688200
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