A Molecular Mechanism for the Heparan Sulfate Dependence of Slit-Robo Signaling

Slit is a large secreted protein that provides important guidance cues in the developing nervous system and in other organs. Signaling by Slit requires two receptors, Robo transmembrane proteins and heparan sulfate (HS) proteoglycans. How HS controls Slit-Robo signaling is unclear. Here we show that...

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Auteurs principaux: Hussain, Sadaf-Ahmahni, Piper, Michael, Fukuhara, Noémi, Strochlic, Laure, Cho, Gian, Howitt, Jason A., Ahmed, Yassir, Powell, Andrew K., Turnbull, Jeremy E., Holt, Christine E., Hohenester, Erhard
Format: Artigo
Langue:Inglês
Publié: 2006
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680705/
https://ncbi.nlm.nih.gov/pubmed/17062560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M609384200
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