Učitavanje...
Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice
Development of neutralizing Abs to blood coagulation factor VIII (FVIII) provides a major complication in hemophilia care. In this study we explored whether modulation of the uptake of FVIII by APCs can reduce its intrinsic immunogenicity. Endocytosis of FVIII by professional APCs is significantly b...
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| Glavni autori: | , , , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society of Hematology
2012
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3680040/ https://ncbi.nlm.nih.gov/pubmed/22498747 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-391680 |
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