Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice

Development of neutralizing Abs to blood coagulation factor VIII (FVIII) provides a major complication in hemophilia care. In this study we explored whether modulation of the uptake of FVIII by APCs can reduce its intrinsic immunogenicity. Endocytosis of FVIII by professional APCs is significantly b...

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Autors principals: Wroblewska, Aleksandra, van Haren, Simon D., Herczenik, Eszter, Kaijen, Paul, Ruminska, Aleksandra, Jin, Sheng-Yu, Zheng, X. Long, van den Biggelaar, Maartje, ten Brinke, Anja, Meijer, Alexander B., Voorberg, Jan
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680040/
https://ncbi.nlm.nih.gov/pubmed/22498747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-391680
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