Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice

Development of neutralizing Abs to blood coagulation factor VIII (FVIII) provides a major complication in hemophilia care. In this study we explored whether modulation of the uptake of FVIII by APCs can reduce its intrinsic immunogenicity. Endocytosis of FVIII by professional APCs is significantly b...

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Detalhes bibliográficos
Main Authors: Wroblewska, Aleksandra, van Haren, Simon D., Herczenik, Eszter, Kaijen, Paul, Ruminska, Aleksandra, Jin, Sheng-Yu, Zheng, X. Long, van den Biggelaar, Maartje, ten Brinke, Anja, Meijer, Alexander B., Voorberg, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Thrombosis and Hemostasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3680040/
https://ncbi.nlm.nih.gov/pubmed/22498747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-11-391680
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