Limited Promiscuity of HLA-DRB1 Presented Peptides Derived of Blood Coagulation Factor VIII

The formation of inhibitory antibodies directed against coagulation factor VIII (FVIII) is a severe complication in the treatment of hemophilia A patients. The induction of anti-FVIII antibodies is a CD4(+) T cell-dependent process. Activation of FVIII-specific CD4(+) T cells is dependent on the pre...

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Main Authors: van Haren, Simon D., Wroblewska, Aleksandra, Herczenik, Eszter, Kaijen, Paul H., Ruminska, Aleksandra, ten Brinke, Anja, Meijer, Alexander B., Voorberg, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828219/
https://ncbi.nlm.nih.gov/pubmed/24244658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080239
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