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Substrate-modulated Cytochrome P450 17A1 and Cytochrome b(5) Interactions Revealed by NMR

The membrane heme protein cytochrome b(5) (b(5)) can enhance, inhibit, or have no effect on cytochrome P450 (P450) catalysis, depending on the specific P450, substrate, and reaction conditions, but the structural basis remains unclear. Here the interactions between the soluble domain of microsomal b...

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Detalhes bibliográficos
Main Authors: Estrada, D. Fernando, Laurence, Jennifer S., Scott, Emily E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675632/
https://ncbi.nlm.nih.gov/pubmed/23620596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.468926
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