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IgG1 Thioether Bond Formation in Vivo
During either production or storage, the LC214-HC220 disulfide in therapeutic antibodies can convert to a thioether bond. Here we report that a thioether forms at the same position on antibodies in vivo. An IgG1κ therapeutic antibody dosed in humans formed a thioether at this position at a rate of a...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3675574/ https://ncbi.nlm.nih.gov/pubmed/23625924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.468397 |
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