Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

Thymic involution during aging is a major cause of decreased production of T cells and reduced immunity. Here we show that inactivation of Rb family genes in young mice prevents thymic involution and results in an enlarged thymus competent for increased production of naive T cells. This phenotype or...

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Main Authors: Garfin, Phillip M., Min, Dullei, Bryson, Jerrod L., Serwold, Thomas, Edris, Badreddin, Blackburn, Clare C., Richie, Ellen R., Weinberg, Kenneth I., Manley, Nancy R., Sage, Julien, Viatour, Patrick
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2013
Assuntos:
Brief Definitive Report
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674705/
https://ncbi.nlm.nih.gov/pubmed/23669396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121716
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