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An organized and functional thymus generated from FOXN1-reprogrammed fibroblasts

A central goal of regenerative medicine is to generate transplantable organs from cells derived or expanded in vitro. Although numerous studies have demonstrated production of defined cell-types in vitro(1), creation of a fully intact organ has not been reported. The transcription factor Forkhead bo...

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Main Authors: Bredenkamp, Nicholas, Ulyanchenko, Svetlana, O’Neill, Kathy Emma, Manley, Nancy Ruth, Vaidya, Harsh Jayesh, Blackburn, Catherine Clare
格式: Artigo
語言:Inglês
出版: 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4153409/
https://ncbi.nlm.nih.gov/pubmed/25150981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3023
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