Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution

Thymus function requires extensive cross-talk between developing T-cells and the thymic epithelium, which consists of cortical and medullary TEC. The transcription factor FOXN1 is the master regulator of TEC differentiation and function, and declining Foxn1 expression with age results in stereotypic...

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Publicat a:PLoS One
Autors principals: O’Neill, Kathy E., Bredenkamp, Nicholas, Tischner, Christin, Vaidya, Harsh J., Stenhouse, Frances H., Peddie, C. Diana, Nowell, Craig S., Gaskell, Terri, Blackburn, C. Clare
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4794177/
https://ncbi.nlm.nih.gov/pubmed/26983083
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0151666
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