Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

Thymic involution during aging is a major cause of decreased production of T cells and reduced immunity. Here we show that inactivation of Rb family genes in young mice prevents thymic involution and results in an enlarged thymus competent for increased production of naive T cells. This phenotype or...

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Bibliografische gegevens
Hoofdauteurs: Garfin, Phillip M., Min, Dullei, Bryson, Jerrod L., Serwold, Thomas, Edris, Badreddin, Blackburn, Clare C., Richie, Ellen R., Weinberg, Kenneth I., Manley, Nancy R., Sage, Julien, Viatour, Patrick
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2013
Onderwerpen:
Brief Definitive Report
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674705/
https://ncbi.nlm.nih.gov/pubmed/23669396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121716
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