Inactivation of the RB family prevents thymus involution and promotes thymic function by direct control of Foxn1 expression

Thymic involution during aging is a major cause of decreased production of T cells and reduced immunity. Here we show that inactivation of Rb family genes in young mice prevents thymic involution and results in an enlarged thymus competent for increased production of naive T cells. This phenotype or...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Garfin, Phillip M., Min, Dullei, Bryson, Jerrod L., Serwold, Thomas, Edris, Badreddin, Blackburn, Clare C., Richie, Ellen R., Weinberg, Kenneth I., Manley, Nancy R., Sage, Julien, Viatour, Patrick
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Rockefeller University Press 2013
Gaiak:
Brief Definitive Report
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674705/
https://ncbi.nlm.nih.gov/pubmed/23669396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20121716
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