Mule/Huwe1/Arf-BP1 suppresses Ras-driven tumorigenesis by preventing c-Myc/Miz1-mediated down-regulation of p21 and p15

Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that influence cellular proliferation, differentiation, apoptosis, and/or senescence. Many gene products involved in these processes are substrates of the E3 ubiquitin ligase Mule/Huwe1/Arf-BP1 (Mule), but whether Mule acts...

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Hauptverfasser: Inoue, Satoshi, Hao, Zhenyue, Elia, Andrew J., Cescon, David, Zhou, Lily, Silvester, Jennifer, Snow, Bryan, Harris, Isaac S., Sasaki, Masato, Li, Wanda Y., Itsumi, Momoe, Yamamoto, Kazuo, Ueda, Takeshi, Dominguez-Brauer, Carmen, Gorrini, Chiara, Chio, Iok In Christine, Haight, Jillian, You-Ten, Annick, McCracken, Susan, Wakeham, Andrew, Ghazarian, Danny, Penn, Linda J.Z., Melino, Gerry, Mak, Tak W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2013
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3672645/
https://ncbi.nlm.nih.gov/pubmed/23699408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.214577.113
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