The E3 ubiquitin ligase Mule acts through the ATM–p53 axis to maintain B lymphocyte homeostasis

Cellular homeostasis is controlled by pathways that balance cell death with survival. Mcl-1 ubiquitin ligase E3 (Mule) is an E3 ubiquitin ligase that targets the proapoptotic molecule p53 for polyubiquitination and degradation. To elucidate the role of Mule in B lymphocyte homeostasis, B cell–specif...

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Main Authors: Hao, Zhenyue, Duncan, Gordon S., Su, Yu-Wen, Li, Wanda Y., Silvester, Jennifer, Hong, Claire, You, Han, Brenner, Dirk, Gorrini, Chiara, Haight, Jillian, Wakeham, Andrew, You-Ten, Annick, McCracken, Susan, Elia, Andrew, Li, Qinxi, Detmar, Jacqui, Jurisicova, Andrea, Hobeika, Elias, Reth, Michael, Sheng, Yi, Lang, Philipp A., Ohashi, Pamela S., Zhong, Qing, Wang, Xiaodong, Mak, Tak W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3260869/
https://ncbi.nlm.nih.gov/pubmed/22213803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20111363
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