Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

The E3 ubiquitin ligase Mule is often overexpressed in human colorectal cancers, but its role in gut tumorigenesis is unknown. Here, we show in vivo that Mule controls murine intestinal stem and progenitor cell proliferation by modulating Wnt signaling via c-Myc. Mule also regulates protein levels o...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Cell Stem Cell
Κύριοι συγγραφείς: Dominguez-Brauer, Carmen, Hao, Zhenyue, Elia, Andrew J., Fortin, Jérôme M., Nechanitzky, Robert, Brauer, Patrick M., Sheng, Yi, Mana, Miyeko D., Chio, Iok In Christine, Haight, Jillian, Pollett, Aaron, Cairns, Robert, Tworzyanski, Leanne, Inoue, Satoshi, Reardon, Colin, Marques, Ana, Silvester, Jennifer, Cox, Maureen A., Wakeham, Andrew, Yilmaz, Omer H., Sabatini, David M., van Es, Johan H., Clevers, Hans, Sato, Toshiro, Mak, Tak W.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2016
Θέματα:
Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5193118/
https://ncbi.nlm.nih.gov/pubmed/27184401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.04.002
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