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E3 ubiquitin ligase Mule ubiquitinates Miz1 and is required for TNFα-induced JNK activation
The zinc finger transcription factor Miz1 is a negative regulator of TNFα-induced JNK activation and cell death through inhibition of TRAF2 K63-polyubiquitination in a transcription-independent manner. Upon TNFα stimulation, Miz1 undergoes K48-linked polyubiquitination and proteasomal degradation, t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2922175/ https://ncbi.nlm.nih.gov/pubmed/20624960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913690107 |
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